P.0647 Psychological impact in patients with common mental disorders after six months of COVID-19 outbreak

Introduction: Studies focused on the impact of the COVID-19 pandemic in patients with psychiatric disorders have reported a deterioration of their mental health due to this situation [1]. A study focused on the early COVID-19 pandemic consequences on mental health found that participants reporting a current mental disorder were experiencing the greatest psychological impact, followed by those reporting a past mental disorder [2]. We hypothesize that having suffered or suffering from a depressive or anxiety disorder at that time can lead to maladaptive responses during the pandemic and social restrictions. Aims of the study: To describe the psychological impact among patients with a current or past diagnosis of Common Mental Disorders (CMD;anxiety and depressive disorders) after six months of the beginning of the COVID-19 pandemic. 1. To explore risk and protective factors associated with a Severe Psychological Impact (SPI). Methods: Cross-sectional survey. A self-reported online test was completed by the participants during the pandemic from October 14th to November 8th, 2020, from all over the Spanish territory. From the sample (N=5900), 1122 (19.02%) reported suffering from CMD in the past or at the moment the study was conducted (mean age±SD=46.01 ±14.12 years) The Spanish version of the Depression, Anxiety and Stress Scale (DASS-21) was used to evaluate the maladaptive psychological responses. Psychological impact in CMD was classified according to the number of maladaptive responses in the DASS-21 scale, considering: mild (1 response), moderate (2 responses) and severe (3 responses). Statistical analyses: Chi-square, t-student test (IBM SPSS version 24 was used for data analyses). The p-value was set at <0.05. Results: Women represented 70.1% of the sample. Approximately half of the participants were married or were living with a cohabiting partner (55.8%). Most of the responders had completed university studies (69.6%). From the sample, 1240 participants (21%) had a somatic disease (12% hypertension and 10.8% chronic respiratory disease). 16.1% increased their alcohol consumption and 14.1% increased their tobacco consumption. CMD reported the highest psychological impact on Depressive DASS-21 subscale (59.5% χ²=206.6, p<0.001), followed by Stress subscale (38.6, χ²= 482.2, p<0.001) and Anxiety subscale (31.3, χ²= 204.7, p<0.001). According to copying strategies, a high percentage of patients with CMD reported being able to enjoy leisure time (88.1%). Reading or listening to music were the most frequent activities (87.8%). 20.7% of the sample showed a SPI. Considering the statistically significant variables, a logistic regression analysis was obtained. On the one hand, older age (B=-0.03, OR=0.972, p<0.001), male sex (B=-0.6, OR=0.55, p=0.008), university studies (B=-0.43, OR=0.652, p=0.008) and being able to enjoy leisure time (B=-1.1, OR=0.341, p<0.001) were protective factors of SPI. On the other hand, having a somatic illness (B=0.59, OR=1.797, p<0.001) and the increase in tobacco use (B=0.58, OR=1.778, p=0.005) were factors associated with SPI. Conclusions: This study illustrates the psychological impact in CMD after half-year of the COVID-19 outbreak. Being young, a woman, suffering from somatic illness, and not having a university education are risk factors for SPI. However, being able to enjoy leisure time is the main protective factor against a SPI in CMD. No conflict of interest

COVID-19 psychological impact in patients with depressive disorder: Differences based on their age

IntroductionCOVID-19 pandemic and lockdown have provoked a considerable psychological impact in Spain. Some studies have reported greater psychological impact in the younger population. To date, no previous study has focused on depressive disorder (DD) patients based on their age.ObjectivesTo describe the psychological impact on DD according to age.MethodsCross-sectional study of an online survey available from 19 to 26 March 2020. Out of a total of 21207 respondents, 608 (2.9%) reported suffering from DD (mean age ±SD = 41.2 years±14.07 [18-82], 80.6% women). The subsample (608) was divided according to age, “youngsters” <45 (57.4%)/ “elders” ≥45. DASS-21 and IES scales were employed. Statistical analyses: Chi-square, t-Student test.ResultsBoth groups did not differ (p>0.05) in sex, having COVID-19 symptoms, having family/friends infected, or income changes. While youngsters were single more frequently (68.8% vs 14.3%, χ² = 179.7, p<0.001), elders had somatic illness more frequently (64.8% vs 39.7% χ² =30.401, p<0.001). Youngsters obtained higher scores in depression (4.69 vs 4.1, T=5.413, p<0.001), anxiety (2.86 vs 1.97, T=5.249, p<0.001) and stress (4.48 vs 3.17, T=6.355, p<0.001) DASS-21 subscales, as in intrusive (3.42 vs 3.05, T=1.984, p=0.048) and avoidant (4.64 vs 4.11, T=3.056, p=0.002) IES scores.ConclusionsDespite the group of elders with depression being more vulnerable to severe COVID-19 disease and presenting more frequently somatic comorbidities, younger depressive patients suffered more from depressive, anxiety, stress and avoidant symptoms and intrusive thoughts, in line with previous reports in the general population.DisclosureNo significant relationships.

P.661 Psychological impact of the COVID-19 outbreak and lockdown in Spanish sample with anxiety disorder: differences according to sex

Introduction: We have experienced the effects of an unprecedented pandemic due to the new coronavirus SARS-CoV-2. This is the causative agent of COVID-19. There are precedents for the imposition of lockdown in previous outbreaks that caused a great psychological impact. Specifically, an increase in the mean post-traumatic stress scores, high depressive symptoms and an increase in completed suicides was reported [1,2]. The severity of the impact on mental health is greater in vulnerable people such as those with a psychiatric history [3,4]. Aims: This study aims 1) to assess the psychological impact on a large sample of participants with an anxiety disorder during the onset of the pandemic and lockdown in Spain;2) to Explore differences in the magnitude of the psychological impact of the people with an anxiety disorder according to the sex. Methods: Secondary analyses of a descriptive and comparative cross-sectional study of the data provided by the participants in an anonymous online survey conducted between March 19 and 26. The ad hoc questionnaire included sociodemographic, clinical data and variables related to COVID-19 as well as questions on coping strategies, and the Spanish versions of the Depression, Anxiety and Stress Scale (DASS-21) and the Impact of Event Scale (IES). From the entire sample of 21207 participants, we analyzed 1617 (7.6%) people with an anxiety disorder at that time [mean age = 35.6 (SD = 12.47);women = 1347 (83.3%)]. For the statistical analysis, the sample was divided into two groups according to sex. We used a chi-square test and Student's t test to detect differences among groups. Next, we analyzed the associations between sex and scores on psychometric scales using logistic regression to control for potential confounding factors. Results: Of the individuals with an anxiety disorder, 55.7% were single, 10.2% lived alone and only 2.4% live with family members infected by SARS-CoV-2. 72.8% do not have children in charge, and 89.1% do not have elderly people dependent on them. Comparing the psychological impact between groups, we observed that it is greater in women. We found statistically significant differences in every DASS-21 subscale: depression (4.35 ± 1.19 vs 4.10 ± 1.28;T= -3.076, p<0.002), anxiety (3.20 ± 2.14 vs 2.41 ± 2.03;T= -5.625, p< 0.001) and stress (4.60 ± 2.15 vs 3.86 ± 2.49;T= -4.540, p< 0.001);and in intrusive (3.63 ± 2.07 vs 2.83 ± 2.09;T= -5.751, p< 0.001) and avoidance subscales of IES (4.72 ± 1.89 vs 3.80 ± 2.06;T= -6.850, p< 0.001). Multivariate analysis revealed a statistically significant association of intrusive thoughts (OR 1.12;IC 95%:1.05-1.21, p=0.001), avoidant thoughts (OR 1.19;IC 95%:1.01-1.29, p<0.001) and age (OR 0.99;IC 95%:0.98-0.99, p=0.004) with being female. Conclusions: Our data indicated that the COVID-19 outbreak and lockdown harmed the mental health of people with mental disorders such as anxiety disorders. After considering confounding variables, we observed that women with an anxiety disorder suffer greater negative repercussions such as intrusive and avoidant thoughts compared to men. No conflict of interest